Characterizing the Clinical Trajectory and Predicting Persistence and Deterioration of Attenuated Psychotic Symptoms in Ultra-High-Risk Individuals

C Wannan; I Scott; D Dwyer; SR Clark; S Hartmann; RR Ye; GP Amminger; HP Yuen; S Lavoie; C Markulev; MR Schaefer; JA Hartmann; N Mossaheb; M Schlögelhofer; S Smesny; IB Hickie; G Berger; EYH Chen; L De Haan; DH Nieman; M Nordentoft; A Riecher-Rössler; S Verma; A Thompson; AR Yung; M Kerr; J Spark; N Wallis; A Polari; PD McGorry; B Nelson

Journal article

Characterizing the Clinical Trajectory and Predicting Persistence and Deterioration of Attenuated Psychotic Symptoms in Ultra-High-Risk Individuals

C Wannan, I Scott, D Dwyer, SR Clark, S Hartmann, RR Ye, GP Amminger, HP Yuen, S Lavoie, C Markulev, MR Schaefer, JA Hartmann, N Mossaheb, M Schlögelhofer, S Smesny, IB Hickie, G Berger, EYH Chen, L De Haan, DH Nieman Show all

Schizophrenia Bulletin | OXFORD UNIV PRESS | Published : 2025

DOI: 10.1093/schbul/sbae204

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Abstract

Background Almost 40% of individuals at ultra-high risk (UHR) for psychosis experience persistent attenuated psychotic symptoms (APS) yet it is unclear (1) whether they share overlapping clinical and functional outcomes compared to individuals who transition to psychosis, (2) when symptom and functioning trajectories begin to diverge between UHR individuals with different clinical outcomes, and (3) whether non-remission (persistent APS or transition) can be predicted using baseline and/or longitudinal data. Study Design Participants were drawn from 2 randomized clinical trials: Neurapro (n = 220; discovery sample) and STEP (n = 180; external validation sample). First, 12-24 month symptoms an..

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University of Melbourne Researchers

Cassandra Wannan Author

Isabelle Scott Author

Dom Dwyer Author

Simon Hartmann Author

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Awarded by Colonial Foundation

Funding Acknowledgements

This work was supported by grant 07TGF-1102 from the Stanley Medical Research Institute, grant 566529 from the NHMRC Australia Program (P.D.M., I.B.H., and A.R.Y., and G.P.A.), a grant from the Colonial Foundation, and a grant from the National Institute of Mental Health under award number 1U01MH105258-01. C.W. was supported by a National Health and Medical Research Council Investigator Grant (2034232). P.D.M. was supported by Senior Principal Research Fellowship 1060996 from the National Health and Medical Research Council of Australia (NHMRC); A.R.Y. and G.P.A. were supported by NHMRC Senior Research Fellowships 1080963 and 566593, respectively; A.R.Y. is supported by an NHMRC Investigator Grant (2026339) and B.N. is supported by a National Health and Medical Research Council Senior Research Fellowship (1137687) and a University of Melbourne Dame Kate Campbell Fellowship.